Algae-inspired adhesive for use in minimally invasive surgeries
The Problem
Current methods of wound closure are inconvenient for internal use, especially in laparoscopy and minimally invasive surgeries, leaving an unmet need in surgeons’ toolbox [1]–[3]. Although sutures have high tensile strength [3], [4], they are prone to infection and their repeated punctures damage surrounding tissues [3], [5]. Further, sutures are time-consuming and complicated to apply to difficult-to-access areas of the body [1], [3]. While some adhesives based on natural polymers are approved for medical use, they are limited by their low adhesion strength, complex preparation procedures, and unfavourable adverse events such as possible disease transmission and thrombosis [2], [3], [6], [7]. Additionally, most of these internal adhesives are only used in very specific surgical procedures for which they are exclusively suited [3], [7].
The Solution
Kelserra proposes to create a biomimetic surgical adhesive inspired by the adhesion mechanism used by brown algae (Fucus serratus) and primarily composed of alginate, phloroglucinol, and calcium ions. Preliminary research has shown that such a formulation can be as strong as commercial fibrin sealant, which is the most commonly used type of internal surgical adhesive, but without any of the health risks associated with fibrin sealants [2]. The primary goal is to develop and test a formulation that will maximize wet adhesion strength, minimize curing time, and maintain biocompatibility for a wide range of laceration lengths. Thus, the aim is to decrease surgery time and improve patient outcomes compared to current internal wound closure methods in minimally invasive surgery.
2023-2024
After doing a comprehensive literature review, the Kelserra team worked in the lab to develop different adhesive formulations and test their properties. Outside of the lab, they also had the opportunity to present their initial findings at the 2024 CUBEC Conference in January 2024. In June, members of the team travelled to New York City to participate in the BioDesign Challenge, where they presented a poster and placed as a top 8 finalist in the competition.
2024-2025
The team will focus on refining their product and working towards a publication.
Sponsorship
Interested in learning more and supporting this project? Check out Kelserra's sponsorship catalog!
Team Leads